Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11262-4

A novel therapeutic modality enforces non-native androgen receptor (AR)–p300/CBP interactions to collapse AR transcriptional programs, producing super-inhibitory, lineage-selective suppression of metastatic prostate cancer and establishing domain-alteration chimeras as a broadly applicable therapeutic strategy leveraging induced proximity.