Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0
Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limiting post-replicative DNA gaps.Backend
Human replisomes direct a dedicated leading-strand primase for fork restart
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Source：https://www.nature.com/articles/s41586-026-11204-0
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