arXiv:2610.41995v1 Announce Type: new Abstract: We study high-dimensional graph combinatorial hypothesis testing problems in which a signal is supported on the edge set of an unknown subgraph drawn from a class invariant under vertex relabeling. For Gaussian observations, we characterize sharp statistical and computational thresholds (at polynomial order) for the signal magnitude required for strong detection across various combinatorial graph alternatives. Our analysis is based on bounding the second moments of the full and low-degree likelihood ratios in terms of the overlap of two independent latent structures and comparing the resulting lower bounds with scan, average, and coordinatewise maximum tests. Under an appropriate low-degree conjecture for computational hardness, we obtain planted-clique thresholds matching those known for Gaussian submatrix detection and identify new statistical-computational gaps for multiple planted cliques and hypercliques, thick cycles and thick paths. We also establish a novel transfer principle across natural exponential family observation models: matching the one-coordinate chi-square divergence preserves full likelihood-ratio second moments exactly and makes low-degree second moments equivalent up to constant factors under a degree condition. Under local regularity, we obtain corresponding testing upper bounds in terms of an effective signal strength. When these upper and lower bounds match, they yield universal threshold scales in the local alternative regime. As a consequence, statistical-computational gaps for planted-clique detection in Erd\H{o}s--R\'enyi settings can be deduced from the Gaussian model.