Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11234-8

A deep single-cell and spatial multi-omic atlas of human glioblastoma is generated, pairing transcriptomic, epigenomic and genomic profiling, and tracing glioblastoma tumour heterogeneity to a stereotyped and spatially patterned trajectory of cancer cells.