Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11308-7
IL-1β from neutrophils and macrophages stabilizes nearby brown adipocytes in a low-UCP1 state; cold temperature reduces IL-1β via sympathetic nerves, leading to transition to a high-UCP1 state and increased thermogenesis, while higher temperatures have the opposite effect.Industry
Bistable regulation of adipocyte heterogeneity governs thermogenesis
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Source：https://www.nature.com/articles/s41586-026-11308-7
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