This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2

Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a benefit, and now scientists are scrambling to work out what that means.