中文 English Français Русский Español العربية

Domain-alteration chimeras rewire oncogenic complexes in prostate cancer

Nature News2026-11-12 03:220 views

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11262-4

A novel therapeutic modality enforces non-native androgen receptor (AR)–p300/CBP interactions to collapse AR transcriptional programs, producing super-inhibitory, lineage-selective suppression of metastatic prostate cancer and establishing domain-alteration chimeras as a broadly applicable therapeutic strategy leveraging induced proximity.

Source：https://www.nature.com/articles/s41586-026-11262-4

My favorites

PreviousThe molecular basis of replication fork restart via repriming by PRIMPOL NextGlycosylation and importins liquefy the FG barrier in live nuclear pores

Congress to call Jensen Huang in to answer for alleged Chinese spy affair

Nvidia CEO Jensen Huang has until the end of the day Wednesday to answer a call from House Republicans for a closed-door

0TechCrunch

With $720M round, Britain’s Fractile gets a leg up in the race for AI chips

Fractile has now become one of the top-funded players in the race for purpose-built AI chips.

0TechCrunch

GitHub Actions fetch-depth: 1 Turned 9 Releases Into 0.1.dev1

Nine nightly builds in a row shipped to our internal package bucket with the exact same version: 0.1.dev1+g3f9c2a1 . The

0dev.to

Part 4 – Cybersecurity journeys: What I’d tell my younger self

Over the past few weeks, I’ve introduced you to people who fell into security from the most unexpected places, who work

0AWS Security Blog

Pixel users are getting a major Android Auto update – and it rivals Siri AI

More phones are getting Gemini Intelligence, but only Pixel users can access it in a new way.

0ZDNet

Developers have been hacking around MCP’s file-upload problem for two years. A fix is taking shape.

The Model Context Protocol (MCP) has played an instrumental part in connecting AI assistants to external tools and data

0The New Stack