Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-y
PRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the high-fidelity polymerase ε, minimizing mutagenic DNA synthesis.Backend
The molecular basis of replication fork restart via repriming by PRIMPOL
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Source：https://www.nature.com/articles/s41586-026-11276-y
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